1.
Chem Pharm Bull (Tokyo)
; 64(8): 1149-53, 2016.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27477654
RESUMO
We have developed a convergent synthesis of dronedarone, an antiarrhythmic agent. The key steps of the process are the construction of a benzofuran skeleton by iodocyclization and the carbonylative Suzuki-Miyaura cross-coupling for biaryl ketone formation. This synthetic route required only eight steps from 2-amino-4-nitrophenol in 23% overall yield.